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Antioxidants, such as thiol donors, inhibit NF-B-induced gene transcription 13

A recent meta-analysis of 21 randomized controlled trials on the effect of folic acid supplementation on endothelial function suggests that this intervention significantly improves flow-mediated dilation percentage (FMD%) and flow-mediated dilation, but not end-diastolic diameter (EDD) or intracellular adhesion molecule 1 (ICAM-1) expression (Zamani et al., 2023)

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Human-Relevant Research Applications

Folates It is well-known that preconceptional folic acid supplementation (400 g per day) both improves folate and decreases homocysteine (Hcy) levels in follicular fluid