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Application of glutathione depletion in cancer therapy: enhanced ROS-based therapy, ferroptosis, and chemotherapy

In addition to dopamine, norepinephrine, and epinephrine, the VMAT transporters, in particular VMAT2, are responsible for vesicular import of serotonin (5-HT), histamine, and several trace amines such as the tyramines [para-tyramine ( p -tyramine), meta-tyramine ( m -tyramine), 3-methoxytyramine, and N-methyltyramine], -phenylethylamine (-PEA), and thyronamine (3-iodothyronamine)

This has three major advantages for researchers: BBB Bypass: No need for the peptide to cross the BBB from the bloodstream

The score values of the seminal cellular system decreased after 4 - 8 weeks of treatment, but were restored 8 weeks after the end of treatment