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In contrast to common obesity, where cardiovascular risk reduction drives intervention, the main rationale for treatment in MC4R -deficient patients shifts toward alleviating mechanical complications (e.g., sleep apnea, osteoarthritis), preventing diabetes (hyperinsulinemia is common despite relative euglycemia), and improving quality of life [30]

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The PbGST 3D structural homology model was used to perform structure-based screening to identify novel compounds that potentially inhibit the Plasmodium GST activity

MT-II ma mniejsz mas (~1024 vs ~1646 Da) i wykazuje aktywno wobec szerszego spektrum receptorw, w tym MC3R i MC4R w OUN

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