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Additional considerations include diabetic retinopathy status (semaglutide may worsen retinopathy in some patients with pre-existing disease, particularly with rapid A1c improvement), history of pancreatitis (use GLP-1 agents with caution), and upcoming surgical procedures (discuss with your surgical/anesthesia team due to effects on gastric emptying)

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Zhang J, He T, Xue L, Guo H

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

Th1 cytokine production generally tends to exert pro-inflammatory effects and may lead to autoimmune conditions such as Hashimotos thyroiditis