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Some studies suggest slightly higher rates of GI side effects with tirzepatide at higher doses
Serious but rare risks requiring immediate medical attention (call 999 or go to A&E if severe) include: Severe, persistent abdominal pain (potential pancreatitis) Signs of gallbladder problems (pain in upper right abdomen, fever, yellowing of skin or eyes) Chest pain, severe palpitations, or shortness of breath Severe mood changes or psychotic symptoms (more commonly associated with stimulants) Signs of severe dehydration or acute kidney injury Patients with pre-existing conditions require particular caution, including those with cardiovascular disease, history of pancreatitis, gallbladder disease, eating disorders, psychiatric conditions, or substance use history
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