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Studies suggest it modulates neurotransmitters like serotonin and dopamine, which are essential for emotional regulation

Propranolol should be discontinued late in pregnancy due to potential neonatal effects

It is commonly utilised in laboratory research involving melanocortin receptor interactions, particularly MC3R and MC4R, and associated peptide signalling pathways

However, its impact on endosomal escape requires careful optimization, as PEG can hinder LNP fusion with endosomal membranes, a phenomenon often referred to as the PEG dilemma 174,175,176