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Combined with the metabolic changes triggered by dual GIP and GLP-1 receptor activation, tiredness during the first several weeks is expected

Its dual-action mechanism targets both GIP and GLP-1 receptors, which contributes to its effectiveness and sets it apart from other medications

Published mechanistic work also describes tirzepatide as having stronger relative activity at the GIP receptor and biased signaling behavior at the GLP-1 receptor, which makes it a useful compound for studying receptor-selective signaling and dual-incretin pathway biology

However, clinically meaningful delay persists throughout treatment