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As these drugs become more widely used for weight loss and metabolic conditions, clinicians and individuals alike are grappling with questions about how appetite-suppressing medications intersect with disordered eating patterns, body image concerns and recovery

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About a quarter of cases are the result of the passage of hard stools, causing local trauma

Its 39-residue sequence is engineered around a GIP backbone rather than the more commonly modified GLP-1 scaffold, a design choice that fundamentally shapes its receptor pharmacology and distinguishes it from earlier dual-agonist candidates that simply chained GLP-1 and glucagon sequences together

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