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The rationale for senolytics is that clearing these cells removes their chronic SASP burden, allowing tissue homeostasis to be partially restored

Combination of G-CSF administration and human amniotic fluid mesenchymal stem cell transplantation promotes peripheral nerve regeneration

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The 50100mg range appears in protocols because it approximates allometric scaling from effective rodent doses, but rigorous human pharmacokinetic data validating those numbers is sparse