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however, there were important limitations to consider, including small sample sizes, a lack of long-term observation, the use of a single species or strain, the lack of in-depth exploration of cellular or molecular mechanisms, failure to assess other aspects of reproductive function, a lack of validation of the clinical relevance, and a failure to consider individual differences in drug dosages

Yet, measures of specific neuropathic impairments (secondary outcomes) improved with lipoic acid supplementation (78)

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We therefore initiated treatment with BSO in the drinking water for both male and female -Myc mice at P21 and maintained it until 8 months of age, unless humane endpoints were reached

Naganuma et al., 2002)