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GIP is also widely considered an adipogenic hormone (Thondam et al., 2017) as it promotes lipid uptake and storage in adipocytes ( Elevated GIP level was associated with the observed increased adiposity induced by a sub-therapeutic antibiotic regimen administered to mice at weaning for 7-weeks, as the treatment did not alter plasma levels of other gut hormones (Lee et al., 2018)

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It happens when there are too many free radicals and not enough antioxidants