Other ROS, including hydrogen peroxide ( H2O2 ) are not, technically speaking, free radicals, but are nevertheless highly reactive
Stracke H, Gaus W, Achenbach U, Federlin K, Bretzel RG
placebo in the fall of eGFR was better among patients with macroalbuminuria or in those with eGFR between 3060 ml/min/1.73 m2,100 and in the AWARD-7 trial the effect of dulaglutide on renal clinical outcomes and eGFR decline was more pronounced in participants with macroalbuminuria at baseline.66 Likewise, in a post hoc analysis of the LEADER study those patients who experienced a 30% reduction in albuminuria during follow-up had fewer cardiovascular and renal events,101 which confirms that a reduction in albuminuria is associated with a reduction in cardiovascular and renal events.99,102 Finally, the renal benefits of arGLP-1 appear to be additive to those of iSGLT2, which is of particular interest in patients with DKD.85,86,103 Cardiovascular and renal benefits of these drugs have been also demonstrated in real-life studies.104105 The causes of renal protection by some arGLP-1 s are unclear
EPMA Journal (2010) 1:343361
The endoplasmic reticulum stress response chaperone: gp96, a host receptor for crohn disease-associated adherent-invasive escherichia coli
