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Examples Canagliflozin (Invokana) Dosage Initial: 100 mg once daily before the first meal of the day Maximum: 300 mg once daily Dapagliflozin (Farxiga) Dosage Initial: 510 mg once daily Maximum: 10 mg once daily Empagliflozin (Jardiance) Dosage Initial: 10 mg once daily Maximum: 25 mg once daily Possible side effects include: Urinary tract infections Genital fungal (mycotic) infections (ie, Candida infection) Hypovolemia (low extracellular fluid) and hypotension (low blood pressure) Acute kidney injury, possibly as a result of volume depletion (limited and contradictory evidence) Diabetic ketoacidosis (rare) Osteoporosis and bone fractures Dipeptidyl peptidase-IV (DPP-4) inhibitors Primary mechanism(s) of action Enhance incretin signaling via inhibition of the enzyme dipeptidyl peptidase-IV (DPP-4), which breaks down GLP-1 and glucose-dependent insulinotropic polypeptide (GIP)

The peptide enhanced satellite cell activation, which is essential for muscle fiber regeneration, and reduced the inflammatory infiltration that can impair healing

TIER 1 (40mg total) $370 total for 8-10 week supply Monthly cost breakdown: $148-$185 based on weekly dose Recommended if new to treatment or for those on 2-5mg/week TIER 2 (60mg total) $445 total for 8-10 week supply Monthly cost breakdown: $178-$220 based on weekly dose Recommended for those on 6-7mg/week TIER 3 (80mg total) $575 total for 8-10 week supply Monthly cost breakdown: $288-$292 based on weekly dose Recommended for those on 8-10mg/week TIER 4 (120mg total) $725 total for 8-10 week supply Monthly cost breakdown: $290-$363 based on weekly dose Recommended for those on 11mg/week and up Custom Semaglutide Injectables Custom-compounded Semaglutide injectables are expertly formulated by our partner pharmacies to support your personalized wellness and weight management goals

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At age 20, plasma levels average approximately 200 ng/mL