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3322-A METHANOBACTIN RESTORES BILIARY COPPER EXCRETION IN WILSON DISEASE RATS VISUALIZED BY 64Cu PET/MRI Emilie Munk 1 , Mikkel Holm Vendelbo 1 , Frederik Teicher Kirk 1 , Mette Irene Theilgaard Simonsen 1 , Aage Kristian Olsen Alstrup 1 , Tamara Rieder 2 , Tea Lund Laursen 1,3 , Peter Ott 1 , Hans Zischka 2,4 and Thomas Damgaard Sandahl 1 , (1)Aarhus University, (2)Technical University Munich, (3)Randers Regional Hospital, (4)Helmholtz Center Munich, German Research Center for Environmental Health Background: Methanobactins (MBs) are small peptides with a very high copper affinity currently under investigation in preclinical trials for the treatment of Wilson disease (WD)
BDNF signaling is frequently downregulated in neurodegenerative conditions, and strategies to restore its levels have demonstrated improvements in synaptic integrity and cognitive outcomes [129, 130]
J Gastroenterol Hepatol
Mitigates the Effects of Stress
