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The success of approved peptides in areas such as diabetes, cancer, and rare diseases demonstrates their clinical utility and has supported continued investment in peptide drug development

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BPC-157 is commonly studied for its involvement in tissue healing and gastrointestinal support, TB-500 for its role in cell migration, angiogenesis, and muscle recovery, and GHK-CU for its effects on skin regeneration, collagen production, and hair-related research

Entinostat (Ent), as a Class I HDAC inhibitor, downregulates pro-fibrotic genes Acta2 and Col1a1, as well as the pro-inflammatory factor LIF, by inhibiting the SRF-FOXM1 transcriptional axis at concentrations of 510 M in vitro , thereby blocking CAF activation and weakening the STAT3 pathway in tumor cells (112)