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DISCLOSURES Cindy Wassef, Radhika Shah, Mahin Alamgir, Samantha Ouellette, and Giulia Frias have no conflicts of interest to disclose

Semaglutide also comes as an oral pill

It stimulates insulin secretion when blood sugar is elevated and suppresses glucagon , the hormone that releases stored sugar into the bloodstream

Patients with worsening gastrointestinal side effects should also avoid alcohol until symptoms resolve

An independent external adjudication committee (EAC) validated prespecified categories of adverse events (including deaths, selected cardiovascular events, malignant neoplasms, thyroid diseases [malignant thyroid neoplasms and C-cell hyperplasia], acute kidney injury, acute pancreatitis, and lactic acidosis) except in SUSTAIN 10 where there was no adjudication