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The guidance is in response to recent case reports and large case series that have shown a risk of retained gastric contents and cases of pulmonary aspiration during sedation for endoscopic procedures or general anaesthesia in individuals treated with GLP-1RAs or GLP-1/GIPRAs
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Future iterations may be weekly oral tablets instead of daily dosing
Adding glucagon receptor (GCGR) agonism to the dual GLP-1R/GIPR profile introduces a mechanism that neither of the predecessor compounds can produce: direct upregulation of energy expenditure through hepatic and thermogenic pathways
But our systems havent forgotten how to regulate appetite
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