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The underlying mechanism is often on-target, off-tumor inhibition of EGFR signaling in keratinocytes, which disrupts skin barrier function and epidermal homeostasis

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For example, some conditions, such as having an underactive thyroid, can affect the way sermorelin works in the body

Supplementation also becomes necessary because certain conditions, such as exposure to chemotherapy, radiation, heavy metals, etc., require a strong antioxidant to help protect the body and rid it of these oxidative stress markers