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The relative effects of induced activation on each of the receptors are likely crucial for optimal efficacy, since for example overly strong activation of GLP1R tends to introduce adverse events (AEs) such as nausea
Thats why subcutaneous injection of large doses (5-10 mg) is the standard delivery method in most epithalon protocols: you have to flood the system to get enough surviving peptide into target tissues before degradation wipes it out
Varghese R, Efferth T, Ramamoorthy S
Additionally, research shows GHS can positively impact body composition by reducing fat and increasing lean tissue
Regarding tubular secretion, CP is actively transported into tubular cells through two membrane transporters, organic cation transporter 2 (OCT2) and copper transporter 1 (CTR1) ( It is currently believed that CP is actively metabolized in the kidney cells to produce a potent nephrotoxic metabolite (Miller et al., 2010)
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