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The SURMOUNT-1 trial, also in the New England Journal of Medicine, studied tirzepatide in adults with obesity or overweight without type 2 diabetes

This precision approach reduces trial-and-error adjustments and helps you achieve results faster with greater confidence

Acute Kidney Injury: Rare cases of acute kidney injury have been reported in patients on semaglutide

The molecule that emerged from this foundational work carried a disabling flaw as a therapeutic scaffold: native GLP-1 is degraded almost immediately by the serine protease dipeptidyl peptidase-4 (DPP-4), which cleaves the peptide between residues 8 and 9 and confers a circulating half-life of under two minutes [4]

Individual Case Reports: The Encouraging Stories Several detailed case reports have been published documenting individual pregnancy outcomes after GLP-1 exposure