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I think it emphasizes the importance of [matching] treatment to the right patient and making sure that we, as clinicians, really counsel patients about what to expect and how to reduce their risk of having those side effects. Both pills target GLP-1 receptors in the body to increase insulin secretion and satiety levels

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To determine the effects of stimulating TCA cycle activity, we treated hepatocytes with dichloroacetate, which stimulates substrate entry into the TCA cycle by inhibiting PDKs (Constantin-Teodosiu, Simpson, & Greenhaff, 1999