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Additionally, studies have demonstrated that removing the insulin receptor in mice decreases blood glucose levels in response to IGF-1, indicating that IGF-1 can compensate for insulin's role in glucose metabolism to some extent (Clemmons, 2004)

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Based on these findings, it was hypothesized that GLP-1derived medications have a potential to cause medullary thyroid carcinoma in humans as well (3,7)

Some people with vitamin B12 deficiency may experience depression or mood changes, and vitamin B12 injections may help to improve mood in these cases