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Korean J Chem Eng 26:16961699 Chen W, Tan H, Liu Q, Zheng X, Zhang H, Liu Y, Xu L (2019) A review: the bioactivities and pharmacological applications of Phellinus linteus

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PE-22-28 (Mini-Spadin) blocks TREK-1 potassium channels with ~100-fold greater potency than its parent compound, demonstrating BDNF upregulation, rapid neurogenesis within 4 days, and cognitive benefits in stroke models (Djillani et al., 2017 in Frontiers in Pharmacology)

Some research shows theres added potential for tirzepatide when its used in conjunction with hormone replacement therapy (HRT)