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Two forms of human COMT have been identified, a cytoplasmic soluble form (SCOMT) and a membranebound form (MBCOMT) located in the cytosolic side of the rough endoplasmic reticulum The SCOMT is predominantly expressed in the human liver, intestine and kidney (Taskinen et al., 2003), whereas the membranebound form is more highly expressed in all regions of the human central nervous system (Tunbridge et al., 2006)

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It is postulated that at the lowest effective plasma GSH concentration is 1 mM