1 2 "Glutathione and mitochondria"
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dose-dependent GI adverse events (nausea, vomiting) similar to other amylin analogues Exposure: Dose-proportional increases in Cmax and AUC Gastric Effects: Dose-dependent slowing of gastric emptying confirmed via paracetamol absorption test Appetite Suppression: Reduced ad libitum food intake at doses 1.2 mg Clinical Significance: Established feasibility of once-weekly dosing and identified dose range for Phase 2 studies
Porciones por envase: 25 Valor Energtico: Energa (caloras): 0 kJ (0 kcal), Grasa total 0 g (0%VD), cidos grasos saturados 0 g (0%VD), Colesterol 0 mg (0%VD), Sodio 0 mg (0%VD), Carbohidratos Totales: 0 g (0%VD), Protena: 0 g (0%VD), Vitamina B5 (cido Pantotnico) 6 mg (60%VD), Vitamina B6 (Piridoxina) 1,2 mg (60%VD), Vitamina C 124 mg (207%VD), Cromo 20 g (17%VD), L Carnitina L Tartrato 3000 mg (*)
Following a 1-week undisturbed period, mice were re-exposed to the shock chamber for a 25-min extinction session in the same context without foot shocks to assess extinction learning
