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The scientific rationale for combining these peptides stems from research demonstrating that GHRH and GHRP pathways act synergistically: GHRH primarily stimulates GH synthesis and amplifies GH pulse amplitude, while GHRPs modulate pulse frequency and timing by acting on distinct receptors and intracellular signaling cascades

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Transfection with hsa-let-7c low-expression virus brought about the upregulation of IGF-1R and the enhanced odonto/osteogenic differentiation in IGF-1-treated SCAPs, as indicated by the upregulation of several odonto/osteogenic markers ( DMP1 /DMP1, COL-I /COL-I, ALP, RUNX2 /RUNX2, OSX /OSX, DSPP /DSP and OCN /OCN) in vitro