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Our results clearly demonstrate that GLP-1 RAs are significantly more effective than popular anti-diabetic drugs, such as Metformin or insulin, at preventing the development of CRC, says the studys co-lead researcher, Nathan Berger, the Hanna-Payne Professor of Experimental Medicine at the Case Western Reserve School of Medicine

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Mediation analysis indicated that weight loss did not attenuate the treatment effect on MACE, while changes in waist circumference accounted for approximately one-third of the cardiovascular benefit

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The comparison between both studies shows the superiority of tirzepatide in weight loss when considering maximum doses