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However, the expression of AADAC in rat tissue is seven-fold lower than the expression in human tissue 18 which may account for the absence of observable flutamide hydrolysis in this rat S9 model

Comment: Commenters requested CMS provide coding guidance on the appropriate device billed under HCPCS code C9761

Liu et al., 2014), a novel dimeric form of the K1 domain, designated K1K1 (Vallarola et al., 2020), the semi-synthetic engineered K1 domain, designed to be multimer by biotin-avidin interaction (Simonneau et al., 2015), a MET-agonistic DNA aptamer (Ueki et al., 2016, 2020), and MET-agonistic synthetic macrocyclic peptides (Sato et al., 2020)

Additionally, commenters noted that these expenses are not negated by the software available for free from the measure steward, as the measure requires working with a third-party vendor