TB-500: systemic healing and skin regeneration Thymosin beta-4, sold as TB-500 , is a 43-amino-acid protein found throughout human tissues
That drop tracks closely with the kind of fatigue, brain fog, and slower recovery that most people write off as just getting older
MT can localize to the intermembrane space, where its N-terminal -domain delivers zinc to components of the electron transport chain, modulating respiration in a zinc-dependent and tissue-specific manner 89
Preliminary evidence suggests that boosting NAD+ levels may support the skins regenerative processes, aiding in cellular repair, supporting mitochondrial function and reducing the buildup of damaged cells
Its also found within amyloid plaques, where it may act as a TREM2 ligand