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Participants who started too high or escalated too quickly in clinical trials experienced nearly double the rate of nausea and vomiting compared to those who followed the gradual protocol

Its important to note that this data is currently limited to psoriasis and psoriatic arthritis

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Efficacy and safety of canagliflozin compared with placebo and sitagliptin in patients with type 2 diabetes on background metformin monotherapy: a randomised trial