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Greene ER, Dong KC, Martin A (2020) Understanding the 26S proteasome molecular machine from a structural and conformational dynamics perspective

Patients can experience multiple OFF-episodes per day with cumulative daily OFF-time accounting for up to 50% of a patients waking day [3, 4], with significant impact on quality of life [5, 6]

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N Engl J Med (2015) 372(4):32030

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