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Twenty-four hours after application on abraded skin the tissue distribution was as follows: liver 139 +/- 34, small intestine 214 +/- 76, large intestine 309 +/- 115, and kidneys 222 +/- 30

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8 weeks: ~5 vials 12 weeks: ~8 vials 16 weeks: ~10 vials Insulin Syringes (U-100, 1 mL) Per injection: 1 syringe 8 weeks (loading daily): ~56 syringes 16 weeks (loading daily): ~112 syringes Bacteriostatic Water (10 mL bottles) Use 2.0 mL per 10 mg vial for reconstitution

In addition to standing up to DPP-4s breakdown action better than analogous human hormones, some of the first-generation GLP-1 drugs, like exenatide, have also been shown to cross the blood-brain barrier in rodents