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Structurally, Tirzepatide is engineered as a hybrid incretin agonist combining the first 14 amino acid residues from native GIP with a GLP-1-derived C-terminal segment (residues 1539) 32
Species-specific action of (Pro3)GIP a full agonist at human GIP receptors, but a partial agonist and competitive antagonist at rat and mouse GIP receptors