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206 Interestingly, chronic GLP-1R activation activates distinct signalling pathways

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It has been shown that modification of the C-3 position can effectively enhance the antiproliferative ability of caudatin against various cancer cell lines compared to the parent compound, presumably due to improved membrane permeability facilitated by increased lipophilicity (Figure 1g) exhibited the highest activity against HepG2 cells (IC 50 3.11 M) ( To summarize, the esterification and glycosylation of C-3 OH might be beneficial for improving bioactivity and lipid solubility