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And of course we have a number of patients with chronic kidney disease who, as you mentioned, pass away presumably prematurely in the absence of the availability of these drugs from cardiovascular causes

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That looks, at first, like the argument settles itself

31 In necrotic femoral head tissue, osteoprotegerin (OPG) expression is downregulated, while the expression of receptor activator of nuclear factor-B (RANK) and its ligand RANKL is upregulated, promoting osteoclastogenesis and disrupting bone remodeling

This insight does not predict individual outcomes but can support provider reasoning about protocol selection and titration strategy