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The main risks are a temporary resurgence of GI side effects (nausea, constipation, diarrhea), temporary appetite suppression reduction during the low-dose titration phase, and a short-term weight loss pause as tirzepatide builds toward therapeutic levels

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Spencer, L., Olawuni, B., & Singh, P

Generally, gastrointestinal adverse events were mild to moderate, mostly occurred during dose titration, and often resolved over time