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Discussion MTX is a potentially toxic agent for the liver, 2 due to its activation of various pathways involving oxidative stress, inflammation, and both intrinsic and extrinsic apoptotic pathways - including pathways such as MAPK and p53

10.1093/ecco-jcc/jjz132 122 LiW.XiaoJ.ZhouX.XuM.HuC.XuX.et al (2015)

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However, several over-the-counter dietary and herbal products, marketed to support thyroid health and to lose weight, contain excessively high amounts of iodine, sometimes above the TUL, and their use should be discouraged, according to the ATA recommendations [22, 34, 52]