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Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes

Within activated macrophages there are distinct changes in TCA cycle activity that lead to the accumulation of TCA cycle intermediates, particularly fumarate and itaconate

They're also at greater risk of low quality of life, though GLP-1 RAs may help improve it hints a 2022 review

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However, many small- and medium-sized cities in Brazil and the Global South lack the institutional capacity to effectively engage residents in climate governance