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In pursuit of the unknown, our research group performed a variety of clinical tests on GSH level quantitation in specific brain regions (the hippocampus, frontal cortices and cingulate cortices) using non-invasive MRS techniques to evaluate GSHs role as an early diagnostic biomarker for AD

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Functionally it is a straightforward GHRH-receptor agonist: it binds the receptor on pituitary somatotrophs and stimulates endogenous, pulsatile GH release, which secondarily raises IGF-1

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Nevertheless, as both GLP-1R and FGF agonists are being investigated for NASH, it seems reasonable to consider a combinatorial approach given their distinct mechanisms of action