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doi: 10.3390/jcm13195801

237,238 Synphilin-1 also significantly decreases p53 expression and transcriptional activity and reduces p53 mRNA levels and p53 promoter transactivation, which are caused mainly by the production of C-terminal products through caspase-3-mediated cleavage

While this allowed for a broader synthesis of available evidence, observational studies are more susceptible to residual confounding and selection bias, which may influence the observed associations