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More recent studies of isolated acini from mouse and rat pancreas showed a small but dose dependent stimulation of amylase release comparable to that induced by VIP or secretin (54, 98)

In girls with TS, p53 signaling was associated with carriage of the G allele of the rs2069502 CDK4 SNP (including a +1.5-fold increase in MDM2 expression, implying a repression of P53 function, 27 and a +1.5-fold increase in ATM expression, implying that DNA damage increased activation of P53

Two cases of pancreatitis have occurred in children treated with riluzole for OCD