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doi: 10.1016/j.cmet.2021.11.010 126 GiacaloneSSpigarioloCBBortoluzziPNazzaroG

The sc infusion was necessary because the GLP-1 molecule is cleared extremely rapidly in the body (intravenous (IV) half-life of 1-2 min.) due to the actions of an enzyme, dipeptidyl peptidase 4 (DPP-4), which inactivates the peptide [13]

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CRISPR-based screening: identifying key regulatory nodes CRISPR-based genetic screening has transformed the proteostasis field by enabling unbiased identification of essential regulatory components and adaptive signaling hubs