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J Clin Invest 2015, 125: 47144728

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However, the buffering capacity becomes limited as impairment of SAT expansion causes IR [22, 23, 24] as the excess fat are deposited in the visceral adipose tissue (VAT) as well as ectopically in the skeletal muscle, liver, kidney, and heart tissues [25]

Anti-aging: Some studies suggest that higher levels of IGF-1 are associated with greater muscle mass and improved physical capacity, which is why its often researched in the context of aging