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The authors hypothesize that this paradoxical worsening is due to a cytokine imbalance, similar to what is seen with the exacerbation of disease after administration of biological treatments like anti-TNF, which increases interferon (IFN)- release and leukocyte chemotaxis [25]

Since muscle tissue is more metabolically active than adipose tissue (fat), loss of muscle mass leads to a reduced metabolic rate

Dhanoa BS, Cogliati T, Satish AG, Bruford EA, Friedman JS

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developed a cancer cell membrane camouflaged Dacarbazine loaded porous silica nanoparticles for the treatment of melanoma