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PMCID: PMC8504390

These are among the most frequently reported side effects in clinical studies of both semaglutide and tirzepatide

A lot of it has to do with provider concerns regarding prior authorization costs and potential coverage for their patients, and sometimes those perceived barriers lead to underprescribing. Pratley said incentivizing providers to screen for CKD may make it become as routine as checking a patients HbA1c

Retatrutide Side Effects Common: Nausea: ~43% at 12mg (TRIUMPH-4) Diarrhea: ~33% Vomiting: ~20% Dysesthesia: 20.9% at 12mg (abnormal skin sensations unique to retatrutide) Discontinuation due to adverse events: 11.3% (TRIUMPH-1, general obesity) / 18.2% (TRIUMPH-4, osteoarthritis population)

Animal experiments shown in Figures 1C , 2 , and 3 and Supplementary material online, Figures S2 and S3 , were performed by S.V