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Week 5-8: Consolidation Later protocol phases involve continued healing progression, transition capability from intensive to maintenance protocols, functional testing of formerly injured areas, and assessment of need for continued support

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12 These clinical outcomes could be future areas of study in patients receiving flat doses of glucarpidase in the rescue setting rather than for the prevention of methotrexate-related AEs

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After four weeks of loading (taking 4 to 6 grams per day), you've saturated the muscles, so the dose can be reduced to maintenance, which is approximately 2 to 3 grams per day