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Sin embargo, los efectos sobre la hemoglobina A1c (HbA1c), un marcador del control glucmico a largo plazo, se evalan tpicamente despus de aproximadamente 3 meses de tratamiento, siguiendo las recomendaciones de la Asociacin Americana de Diabetes (ADA)

However, native GLP-1 undergoes rapid enzymatic degradation by dipeptidyl peptidase-4 (DPP-4), resulting in a short half-life (~ 2 min), thus limiting its clinical applicability [65, 66]

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