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A., & Campbell, J

Depression model mice were found to have significantly abnormal expression of cholesterol metabolism-related genes (e.g., HMGCR , CYP46A1 , ABCA1 , APOE , etc.) in the prefrontal region, accompanied by a decrease in the synaptic proteins PSD-95 and synaptophysin, suggesting that an imbalance in cholesterol metabolism not only affects synaptic plasticity in neurons but also directly induces depressive behaviors (33)

Intermediate dose