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We have been careful not to make our meta-analyses a prominent component of the review, but rather to use the data to identify the extent of confounding and selection biases and to examine possible sources of heterogeneity between the results of individual observational studies

25400 g/mL), with a statistically significant dose-dependent decrease only at the highest concentrations (200 and 400 g/mL) [125]

In the Phase 3 database, the mean HbA1c increase was approximately 0.1 to 0.2 percent at 52 weeks, clinically minor for most subjects but relevant for anyone with pre-existing insulin resistance or type 2 diabetes