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-0.4% for placebo) Weight loss: Average weight loss over 36 weeks: -10.1 kg (15 mg dose group) Significantly superior to subcutaneous semaglutide (-6.2 kg) Gastrointestinal adverse reactions: Nausea (14% vs

With regard to the increased secretion of EVs during the progression of NAFLD, experimental studies demonstrated that toxic lipids significantly increase the production of hepatocyte-derived EVs, which act as mediators of paracrine signaling, causing hepatic stellate cell activation, angiogenesis and activation of macrophages leading to inflammation and chemotaxis [103,104,105]

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